Adenosine receptor ligands with oxygenated N6-substituents

S A Hutchinson; S P Baker; P J Scammells

doi:10.1016/s0960-894x(99)00109-2

Adenosine receptor ligands with oxygenated N6-substituents

Bioorg Med Chem Lett. 1999 Apr 5;9(7):933-6. doi: 10.1016/s0960-894x(99)00109-2.

Authors

S A Hutchinson¹, S P Baker, P J Scammells

Affiliation

¹ School of Biological & Chemical Sciences, Deakin University, Geelong, Vic, Australia.

PMID: 10230614
DOI: 10.1016/s0960-894x(99)00109-2

Abstract

A number of novel adenosine analogs bearing oxygenated substituents in the N6-position have been prepared and evaluated as A1 adenosine agonists. Improved conditions for the synthesis of N6-substituted adenosines and a new one pot procedure for the synthesis of 2-amino-7-oxabicyclo[2.2.1]hept-5-ene are also reported.

MeSH terms

Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Ligands
Oxygen / chemistry
Purinergic P1 Receptor Agonists*
Receptors, Purinergic P1 / metabolism

Substances

2-amino-7-oxabicyclo(2.2.1)hept-5-ene
Bridged Bicyclo Compounds, Heterocyclic
Ligands
Purinergic P1 Receptor Agonists
Receptors, Purinergic P1
Oxygen